Ventral Striatum Functional Connectivity during Rewards and Losses and Symptomatology in Depressed Patients.

ABSTRACT:

Background

The ventral striatum (VS) and striatal network supports goal motivated behavior. Identifying how depressed patients differ in their striatal network during the processing of emotionally salient events is a step towards uncovering biomarkers for diagnosis and treatment.

Methods

38 depressed and 30 healthy adults completed a task that examined brain activation to the anticipation and receipt of monetary rewards and losses. Data were collected using a 3T Siemens Trio scanner. Functional connectivity differences were examined with seeds in the Left or Right VS. FC estimates were regressed on specific symptoms.

Results

Depressed patients displayed higher functional connectivity between the VS and midline cortical areas during loss versus reward trials. Anhedonia

SUBMITTER: Quevedo K 

PROVIDER: S-EPMC5737904 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature