A comprehensive analysis on preservation patterns of gene co-expression networks during Alzheimer's disease progression.

ABSTRACT:

Background

Alzheimer's disease (AD) is a chronic neuro-degenerative disruption of the brain which involves in large scale transcriptomic variation. The disease does not impact every regions of the brain at the same time, instead it progresses slowly involving somewhat sequential interaction with different regions. Analysis of the expression patterns of the genes in different regions of the brain influenced in AD surely contribute for a enhanced comprehension of AD pathogenesis and shed light on the early characterization of the disease.

Results

Here, we have proposed a framework to identify perturbation and preservation characteristics of gene expression patterns across six distinct regions of the brain ("EC", "HIP", "PC", "MTG", "SFG", and "VCX") affected in AD. Co-expressi

SUBMITTER: Ray S 

PROVIDER: S-EPMC5738049 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature