Cross-sectional variations of white and grey matter in older hypertensive patients with subjective memory complaints.

ABSTRACT: Mild cognitive impairment and Alzheimer's dementia involve a grey matter disease, quantifiable by ¹⁸F-Fluorodeoxyglucose positron emission tomography (FDG-PET), but also white matter damage, evidenced by diffusion tensor magnetic resonance imaging (DTI), which may play an additional pathogenic role. This study aimed to determine whether such DTI and PET variations are also interrelated in a high-risk population of older hypertensive patients with only subjective memory complaints (SMC). Sixty older hypertensive patients (75 ± 5 years) with SMC were referred to DTI and FDG-PET brain imaging, executive and memory tests, as well as peripheral and central blood pressure (BP) measurements. Mean apparent diffusion coefficient (ADC_mean) was determined in overall white matter

SUBMITTER: Chetouani A 

PROVIDER: S-EPMC5738235 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature