Celiac disease is uncommon in irritable bowel syndrome in the USA.

ABSTRACT:

Background and aims

Routine serologic testing for celiac disease (CD) may be useful in irritable bowel syndrome (IBS) patients, but this is controversial. We aimed to compare the prevalence of unrecognized CD in a large cohort of patients with and without IBS.

Participants and methods

This is a family case-control IBS study conducted at a single US academic medical center. Stored serum and DNA were available. Tissue transglutaminase (TTg) immunoglobulin A was performed, followed by indirect immunofluorescence testing for endomysial antibodies with positive or weakly positive TTg results. Individuals were considered to have CD if both results were positive. χ and Fisher's exact tests were used to compare prevalence between the two groups.

Results

Serum samples were stu

SUBMITTER: Almazar AE 

PROVIDER: S-EPMC5738260 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature