MicroRNAs associated with inflammation in shoulder tendinopathy and glenohumeral arthritis.

ABSTRACT: Inflammation is associated with glenohumeral arthritis and rotator cuff tendon tears. Epigenetically, miRNAs tightly regulate various genes involved in the inflammatory response. Alterations in the expression profile of miRNAs and the elucidation of their target genes with respect to the pathophysiology could improve the understanding of their regulatory role and therapeutic potential. Here, we screened key miRNAs that mediate inflammation and linked with JAK2/STAT3 pathway with respect to the coincidence of glenohumeral arthritis in patients suffering from rotator cuff injury (RCI). Human resected long head of the biceps tendons were examined for miRNA profile from two groups of patients: Group 1 included the patients with glenohumeral arthritis and massive rotator cuff tears and the Grou

SUBMITTER: Thankam FG 

PROVIDER: S-EPMC5738295 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature