Modeling of autophagy-related gene expression dynamics during long term fasting in European eel (Anguilla anguilla).

ABSTRACT: Autophagy is an evolutionary conserved cellular self-degradation process considered as a major energy mobilizing system in eukaryotes. It has long been considered as a post-translationally regulated event, and the importance of transcriptional regulation of autophagy-related genes (atg) for somatic maintenance and homeostasis during long period of stress emerged only recently. In this regard, large changes in atg transcription have been documented in several species under diverse types of prolonged catabolic situations. However, the available data primarily concern atg mRNA levels at specific times and fail to capture the dynamic relationship between transcript production over time and integrated phenotypes. Here, we present the development of a statistical model describing the dynamics of

SUBMITTER: Bolliet V 

PROVIDER: S-EPMC5738402 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature