The sigma-1 receptor modulates methamphetamine dysregulation of dopamine neurotransmission.

ABSTRACT: Dopamine neurotransmission is highly dysregulated by the psychostimulant methamphetamine, a substrate for the dopamine transporter (DAT). Through interactions with DAT, methamphetamine increases extracellular dopamine levels in the brain, leading to its rewarding and addictive properties. Methamphetamine also interacts with the sigma-1 receptor (σ₁R), an inter-organelle signaling modulator. Using complementary strategies, we identified a novel mechanism for σ₁R regulation of dopamine neurotransmission in response to methamphetamine. We found that σ₁R activation prevents methamphetamine-induced, DAT-mediated increases in firing activity of dopamine neurons. In vitro and in vivo amperometric measurements revealed that σ₁R activation decreases metha

SUBMITTER: Sambo DO 

PROVIDER: S-EPMC5738444 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature