Microcirculation improvement after short-term infusion of vasopressin in septic shock is dependent on noradrenaline.

ABSTRACT:

Objectives

To assess the impact of vasopressin on the microcirculation and to develop a predictive model to estimate the probability of microcirculatory recruitment in patients with septic shock.

Methods

This prospective interventional study included patients with septic shock receiving noradrenaline for less than 48 hours. We infused vasopressin at 0.04 U/min for one hour. Hemodynamic measurements, including sidestream dark-field imaging, were obtained immediately before vasopressin infusion, 1 hour after vasopressin infusion and 1 hour after vasopressin withdrawal. We defined patients with more than a 10% increase in total vascular density and perfused vascular density as responders. ClinicalTrials.gov: NCT02053675.

Results

Eighteen patients were included, and nine

SUBMITTER: Nascente APM 

PROVIDER: S-EPMC5738558 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature