Multiomic disease signatures converge to cytotoxic CD8 T cells in primary Sjogren's syndrome.

ABSTRACT:

Objectives

Multiomics study was conducted to elucidate the crucial molecular mechanisms of primary Sjögren's syndrome (SS) pathology.

Methods

We generated multiple data set from well-defined patients with SS, which includes whole-blood transcriptomes, serum proteomes and peripheral immunophenotyping. Based on our newly generated data, we performed an extensive bioinformatic investigation.

Results

Our integrative analysis identified SS gene signatures (SGS) dysregulated in widespread omics layers, including epigenomes, mRNAs and proteins. SGS predominantly involved the interferon signature and ADAMs substrates. Besides, SGS was significantly overlapped with SS-causing genes indicated by a genome-wide association study and expression trait loci analyses. Combining the m

SUBMITTER: Tasaki S 

PROVIDER: S-EPMC5738597 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature