Amino acid transporter SLC6A14 is a novel and effective drug target for pancreatic cancer.

ABSTRACT:

Background and purpose

Pancreatic cancer is a solid tumour that is often fatal. Hence, there is an urgent need to identify new drug targets for this disease. Highly proliferating cancer cells have an increased demand for nutrients and, therefore, need to up-regulate selective amino acid transporters. Here, we investigated which amino acid transporters are up-regulated in pancreatic cancer and whether any of these transporters has potential as a drug target for this fatal disease.

Experimental approach

The expression of amino acid transporters in pancreatic cancer was analysed using publicly available microarray datasets, and the findings with the transporter SLC6A14 were validated by mRNA and protein analysis. The potential of SLC6A14 as a drug target was evaluated using a p

SUBMITTER: Coothankandaswamy V 

PROVIDER: S-EPMC5738662 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature