BtsT, a Novel and Specific Pyruvate/H+ Symporter in Escherichia coli.

ABSTRACT: The peptide transporter carbon starvation (CstA) family (transporter classification [TC] 2.A.114) belongs to the second largest superfamily of secondary transporters, the amino acid/polyamine/organocation (APC) superfamily. No representative of the CstA family has previously been characterized either biochemically or structurally, but we have now identified the function of one of its members, the transport protein YjiY of Escherichia coli Expression of the yjiY gene is regulated by the LytS-like histidine kinase BtsS, a sensor of extracellular pyruvate, together with the LytTR-like response regulator BtsR. YjiY consists of 716 amino acids, which form 18 putative transmembrane helices. Transport studies with intact cells provided evidence that YjiY is a specific and high-affinity transporte

SUBMITTER: Kristoficova I 

PROVIDER: S-EPMC5738728 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature