Metabolic regulations of a decoction of Hedyotis diffusa in acute liver injury of mouse models.

ABSTRACT:

Background

Dysfunctional metabolisms are contributed to LPS/GALN-induced hepatitis. However, whether Hedyotis diffusa (HD) employs metabolic strategies against hepatitis is unknown.

Methods

We use the cytokines expression, levels of serum alanine transaminase and aspartate transaminase, survival and histological analysis to measure the effect of decoction of HD on acute severe hepatitis of mouse induced by LPS/GALN. Meanwhile, we utilize GC/MS-based metabolomics to characterize the variation of metabolomes.

Results

The present study shows the relieving liver damage in HD decoction-treated mice. Metabolic category using differential metabolites indicates the lower percentage of carbohydrates in LPS/GALN + HD group than LPS/GALN group, revealing the value of carb

SUBMITTER: Dai M 

PROVIDER: S-EPMC5738817 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature