Genes uniquely expressed in human growth plate chondrocytes uncover a distinct regulatory network.

ABSTRACT:

Background

Chondrogenesis is the earliest stage of skeletal development and is a highly dynamic process, integrating the activities and functions of transcription factors, cell signaling molecules and extracellular matrix proteins. The molecular mechanisms underlying chondrogenesis have been extensively studied and multiple key regulators of this process have been identified. However, a genome-wide overview of the gene regulatory network in chondrogenesis has not been achieved.

Results

In this study, employing RNA sequencing, we identified 332 protein coding genes and 34 long non-coding RNA (lncRNA) genes that are highly selectively expressed in human fetal growth plate chondrocytes. Among the protein coding genes, 32 genes were associated with 62 distinct human skeletal dis

SUBMITTER: Li B 

PROVIDER: S-EPMC5738906 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature