Structure and properties of slow-resorbing nanofibers obtained by (co-axial) electrospinning as tissue scaffolds in regenerative medicine.

ABSTRACT: With the rapid advancement of regenerative medicine technologies, there is an urgent need for the development of new, cell-friendly techniques for obtaining nanofibers-the raw material for an artificial extracellular matrix production. We investigated the structure and properties of PCL₁₀ nanofibers, PCL₅/PCL₁₀ core-shell type nanofibers, as well as PCL₅/PCL_Ag nanofibres prepared by electrospinning. For the production of the fiber variants, a 5-10% solution of polycaprolactone (PCL) (M_w = 70,000-90,000), dissolved in a mixture of formic acid and acetic acid at a ratio of 70:30 m/m was used. In order to obtain fibers containing PCL_Ag 1% of silver nanoparticles was added. The electrospin was conducted using the abov

SUBMITTER: Hudecki A 

PROVIDER: S-EPMC5738967 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature