Mediator 1 Is Atherosclerosis Protective by Regulating Macrophage Polarization.

ABSTRACT:

Objective

MED1 (mediator 1) interacts with transcription factors to regulate transcriptional machinery. The role of MED1 in macrophage biology and the relevant disease state remains to be investigated.

Approach and results

To study the molecular mechanism by which MED1 regulates the M1/M2 phenotype switch of macrophage and the effect on atherosclerosis, we generated MED1/apolipoprotein E (ApoE) double-deficient (MED1^ΔMac/ApoE^-/-) mice and found that atherosclerosis was greater in MED1^ΔMac/ApoE^-/- mice than in MED1^fl/fl/ApoE^-/- littermates. The gene expression of M1 markers was increased and that of M2 markers decreased in both aortic wall and peritoneal macrophages from MED1^ΔMac/ApoE

SUBMITTER: Bai L 

PROVIDER: S-EPMC5739054 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature