Variant Histone H2afv reprograms DNA methylation during early zebrafish development.

ABSTRACT: The DNA methylome is re-patterned during discrete phases of vertebrate development. In zebrafish, there are 2 waves of global DNA demethylation and re-methylation: the first occurs before gastrulation when the parental methylome is changed to the zygotic pattern and the second occurs after formation of the embryonic body axis, during organ specification. The occupancy of the histone variant H2A.Z and regions of DNA methylation are generally anti-correlated, and it has been proposed that H2A.Z restricts the boundaries of highly methylated regions. While many studies have described the dynamics of methylome changes during early zebrafish development, the factors involved in establishing the DNA methylation landscape in zebrafish embryos have not been identified. We test the hypothesis that t

SUBMITTER: Madakashira B 

PROVIDER: S-EPMC5739095 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature