Plasmodium UIS3 sequesters host LC3 to avoid elimination by autophagy in hepatocytes.

ABSTRACT: The causative agent of malaria, Plasmodium, replicates inside a membrane-bound parasitophorous vacuole (PV), which shields this intracellular parasite from the cytosol of the host cell ¹ . One common threat for intracellular pathogens is the homeostatic process of autophagy, through which cells capture unwanted intracellular material for lysosomal degradation ² . During the liver stage of a malaria infection, Plasmodium parasites are targeted by the autophagy machinery of the host cell, and the PV membrane (PVM) becomes decorated with several autophagy markers, including LC3 (microtubule-associated protein 1 light chain 3) ^3,4 . Here we show that Plasmodium berghei parasites infecting hepatic cells rely on the PVM transmembrane protein UIS3 to avoid elimina

SUBMITTER: Real E 

PROVIDER: S-EPMC5739284 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature