Dynamic biofilm architecture confers individual and collective mechanisms of viral protection.

ABSTRACT: In nature, bacteria primarily live in surface-attached, multicellular communities, termed biofilms ^1-6 . In medical settings, biofilms cause devastating damage during chronic and acute infections; indeed, bacteria are often viewed as agents of human disease ⁷ . However, bacteria themselves suffer from diseases, most notably in the form of viral pathogens termed bacteriophages ^8-12 , which are the most abundant replicating entities on Earth. Phage-biofilm encounters are undoubtedly common in the environment, but the mechanisms that determine the outcome of these encounters are unknown. Using Escherichia coli biofilms and the lytic phage T7 as models, we discovered that an amyloid fibre network of CsgA (curli polymer) protects biofilms against phage attack vi

SUBMITTER: Vidakovic L 

PROVIDER: S-EPMC5739289 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature