Association of toll-like receptors polymorphism and intrauterine transmission of cytomegalovirus.

ABSTRACT:

Background

Congenital Cytomegalovirus (CMV) is a very common intrauterine infection which can cause severe developmental disabilities. Transmission of the virus to the fetus occurs in only 40% of primarily infected women. The probability of intrauterine transmission is higher when infection occurs during the second trimester of pregnancy than in the first trimester. The Toll-like receptors (TLRs) protein family plays a key role in both innate immune response to CMV infections and in normal pregnancy. Specific single nucleotide polymorphisms (SNPs) in TLRs can affect CMV infections and maternal-fetal interface expression. Therefore, TLR SNPs could be involved in intrauterine transmission determination.

Study aim

To establish a correlation between TLR2 (rs4696480, rs3804100, r

SUBMITTER: Eldar-Yedidia Y 

PROVIDER: S-EPMC5739442 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature