Breakthrough seizures-Further analysis of the Standard versus New Antiepileptic Drugs (SANAD) study.

ABSTRACT:

Objectives

To develop prognostic models for risk of a breakthrough seizure, risk of seizure recurrence after a breakthrough seizure, and likelihood of achieving 12-month remission following a breakthrough seizure. A breakthrough seizure is one that occurs following at least 12 months remission whilst on treatment.

Methods

We analysed data from the SANAD study. This long-term randomised trial compared treatments for participants with newly diagnosed epilepsy. Multivariable Cox models investigated how clinical factors affect the probability of each outcome. Best fitting multivariable models were produced with variable reduction by Akaike's Information Criterion. Risks associated with combinations of risk factors were calculated from each multivariable model.

Results

Sig

SUBMITTER: Bonnett LJ 

PROVIDER: S-EPMC5739445 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature