Comparative transcriptome analyses reveal the genetic basis underlying the immune function of three amphibians' skin.

ABSTRACT: Skin as the first barrier against external invasions plays an essential role for the survival of amphibians on land. Understanding the genetic basis of skin function is significant in revealing the mechanisms underlying immunity of amphibians. In this study, we de novo sequenced and comparatively analyzed skin transcriptomes from three different amphibian species, Andrias davidianus, Bufo gargarizans, and Rana nigromaculata Hallowell. Functional classification of unigenes in each amphibian showed high accordance, with the most represented GO terms and KEGG pathways related to basic biological processes, such as binding and metabolism and immune system. As for the unigenes, GO and KEGG distributions of conserved orthologs in each species were similar, with the predominantly enriched pathway

SUBMITTER: Fan W 

PROVIDER: S-EPMC5739465 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature