What matters in chronic Burkholderia cenocepacia infection in cystic fibrosis: Insights from comparative genomics.

ABSTRACT: Burkholderia cenocepacia causes severe pulmonary infections in cystic fibrosis (CF) patients. Since the bacterium is virtually untreatable by antibiotics, chronic infections persist for years and might develop into fatal septic pneumonia (cepacia syndrome, CS). To devise new strategies to combat chronic B. cenocepacia infections, it is essential to obtain comprehensive knowledge about their pathogenesis. We conducted a comparative genomic analysis of 32 Czech isolates of epidemic clone B. cenocepacia ST32 isolated from various stages of chronic infection in 8 CF patients. High numbers of large-scale deletions were found to occur during chronic infection, affecting preferentially genomic islands and nonessential replicons. Recombination between insertion sequences (IS) was inferred as the m

SUBMITTER: Nunvar J 

PROVIDER: S-EPMC5739508 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature