MRNA expression profiles obtained from microdissected pancreatic cancer cells can predict patient survival.

ABSTRACT:

Background

Pancreatic ductal adenocarcinoma (PDAC) is one of the most devastating malignancies in developed countries because of its very poor prognosis and high mortality rates. By the time PDAC is usually diagnosed only 20-25% of patients are candidates for surgery, and the rate of survival for this cancer is low even when a patient with PDAC does undergo surgery. Lymph node invasion is an extremely bad prognosis factor for this disease.

Methods

We analyzed the mRNA expression profile in 30 PDAC samples from patients with resectable local disease (stages I and II). Neoplastic cells were isolated by laser-microdissection in order to avoid sample 'contamination' by non-tumor cells. Due to important differences in the prognoses of PDAC patients with and without lymph node inv

SUBMITTER: Garcia-Garcia AB 

PROVIDER: S-EPMC5739601 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature