Hepatitis B virus (HBV) X gene mutations and their association with liver disease progression in HBV-infected patients.

ABSTRACT: Hepatitis B virus (HBV) is one of the most widespread human pathogens causing chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC). This study investigated the clinical impact of single and combinational mutations in HBx gene on the pathogenesis of HCC during progressive stages of liver disease. The patients were categorized into inactive HBV carriers, active carriers, cirrhosis and HCC groups based on disease severity. Male sex, age > 50 years, and high serum alanine aminotransferase level were associated with risk of progressive liver disease. I127T, V131I, and F132Y/I/R mutations showed a significant increasing trend associated with the disease progression to HCC. H94Y and K130M mutations were also significantly associated with severe liver disease. One double mutation

SUBMITTER: Al-Qahtani AA 

PROVIDER: S-EPMC5739625 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature