Role of VEGFA gene polymorphisms in colorectal cancer patients who treated with bevacizumab.

ABSTRACT:

Objectives

This study aimed to explore the effects of vascular endothelial growth factor A (VEGFA) gene polymorphisms (rs699947 and rs833061) on Bevacizumab (BEV) treatment in colorectal cancer (CRC) patients.

Methods

125 CRC cases receiving BEV plus FOLFIRI treatment were recruited in this study. VEGFA polymorphisms were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Correlation of VEGFA gene polymorphisms with the response rate and progression free survival (PFS) was evaluated. Multivariate analyses were performed to estimate the effects of VEGFA polymorphisms on the therapeutic effects of BEV treatment in CRC patients.

Results

Rs699947 variants did not show significant association wi

SUBMITTER: Cui W 

PROVIDER: S-EPMC5739652 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature