A molecular signature of lung cancer: potential biomarkers for adenocarcinoma and squamous cell carcinoma.

ABSTRACT: Adenocarcinoma (AC) and squamous cell carcinoma (SCC), sub-types of non-small cell lung cancer (NSCLC), both present unique features at the genome, epigenome, transcriptome and proteome levels, as well as shared clinical and histopathological characteristics, but differ in terms of treatment. To ensure proper treatment, one must be able to distinguish between these sub-types. Here, we identify novel biomarker proteins in NSCLC, allowing for distinguishing between the AC and SCC sub-types. Proteomics analysis distinguished between healthy and tumor tissues, with the expression level of 1,494 proteins being altered, 378 of which showed a ≥|100|-fold change. Enrichment of proteins related to protein synthesis and degradation, and of proteins associated with mitochondria, metabolism, and apopt

SUBMITTER: Shoshan-Barmatz V 

PROVIDER: S-EPMC5739654 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature