RNA-sequencing reveals genome-wide long non-coding RNAs profiling associated with early development of diabetic nephropathy.

ABSTRACT:

Background

Diabetic nephropathy (DN) seriously threatens the lives of patients, and the mechanism of DN remains largely unknown because of the complex regulation between long non-coding RNA (lncRNA) and protein-coding genes. In early development of diabetic nephropathy (DN), pathogenesis remains largely unknown.

Results

We used RNA-sequencing to profile protein-coding and lncRNA gene transcriptome of mouse kidney proximal tubular cells during early stage of DN at various time points. Over 7000 protein-coding and lncRNA genes were differentially expressed, and most of them were time-specific. Nearly 40% of lncRNA genes overlapped with functional element signals using CHIP-Seq data from ENCODE database. Disease progression was characterized by lncRNA expression patterns, rathe

SUBMITTER: Tang W 

PROVIDER: S-EPMC5739683 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature