Echocardiographic aortic valve calcification and outcomes in women and men with aortic stenosis.

ABSTRACT:

Objective

Sex differences in risk factors of aortic valve calcification (AVC) by echocardiography have not been reported from a large prospective study in aortic stenosis (AS).

Methods

AVC was assessed using a prognostically validated visual score and grouped into none/mild or moderate/severe AVC in 1725 men and women with asymptomatic AS in the Simvastatin Ezetimibe in Aortic Stenosis study. The severity of AS was assessed by the energy loss index (ELI) taking pressure recovery in the aortic root into account.

Results

More men than women had moderate/severe AVC at baseline despite less severe AS by ELI (p<0.01). Moderate/severe AVC at baseline was independently associated with lower aortic compliance and more severe AS in both sexes, and with increased high-sensitive

SUBMITTER: Thomassen HK 

PROVIDER: S-EPMC5739834 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature