Prebiotic inulin-type fructans induce specific changes in the human gut microbiota.

ABSTRACT:

Objective

Contrary to the long-standing prerequisite of inducing selective (ie, bifidogenic) effects, recent findings suggest that prebiotic interventions lead to ecosystem-wide microbiota shifts. Yet, a comprehensive characterisation of this process is still lacking. Here, we apply 16S rDNA microbiota profiling and matching (gas chromatography mass spectrometry) metabolomics to assess the consequences of inulin fermentation both on the composition of the colon bacterial ecosystem and faecal metabolites profiles.

Design

Faecal samples collected during a double-blind, randomised, cross-over intervention study set up to assess the effect of inulin consumption on stool frequency in healthy adults with mild constipation were analysed. Faecal microbiota composition and metabolite

SUBMITTER: Vandeputte D 

PROVIDER: S-EPMC5739857 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature