PD-1 expression on CD8⁺ T cells regulates their differentiation within lung allografts and is critical for tolerance induction.

ABSTRACT: Immunological requirements for rejection and tolerance induction differ between various organs. While memory CD8⁺ T cells are considered a barrier to immunosuppression-mediated acceptance of most tissues and organs, tolerance induction after lung transplantation is critically dependent on central memory CD8⁺ T lymphocytes. Here we demonstrate that costimulation blockade-mediated tolerance after lung transplantation is dependent on programmed cell death 1 (PD-1) expression on CD8⁺ T cells. In the absence of PD-1 expression, CD8⁺ T cells form prolonged interactions with graft-infiltrating CD11c⁺ cells; their differentiation is skewed towards an effector memory phenotype and grafts are rejected acutely. These findings extend the notion th

SUBMITTER: Takahashi T 

PROVIDER: S-EPMC5739961 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature