Prophylactic immunization with human papillomavirus vaccines induces oral immunity in mice.

ABSTRACT:

Objective

Although it has been shown that prophylactic vaccination can induce genital immunity, there is inadequate information on human papillomavirus (HPV) vaccine-induced oral immunity, which is of particular interest due to HPV-associated oropharyngeal malignancies and recurrent respiratory papillomatosis. Therefore, we assessed the efficacy of various HPV vaccines against oral HPV pseudovirus (PsV) infection in mice.

Study design

Preclinical scientific investigation.

Methods

C57BL/6 mice were vaccinated three times at 2-week intervals with either Gardasil (Merck, Kenilworth, NJ) (50 µL intramuscular injection) or a candidate pan-HPV L2 vaccine with alum adjuvant (25 µg subcutaneous injection). Additional mice were immunized with passive transfer of either Gardasi

SUBMITTER: Ahn J 

PROVIDER: S-EPMC5739972 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature