Hepatocyte-derived exosomes promote T follicular regulatory cell expansion during hepatitis C virus infection.

ABSTRACT: Hepatitis C virus (HCV) is a global health concern that can cause severe liver disease, such as cirrhosis and hepatocellular carcinoma. Control of HCV requires vigorous T-cell responses, yet CD4⁺ T cells in chronic HCV patients are dysfunctional. T follicular regulatory (Tfr) cells are a subset of regulatory T cells that suppress T follicular helper (Tfh) cells and the generation of high affinity antibody-producing B cells. In this study, we examined the accumulation of Tfr cells in the liver compartment during chronic HCV infection and defined the cellular and molecular mechanisms underlying their expansion. Our analysis revealed a substantial population of Tfr cells in livers of chronic HCV patients that is absent in liver tissues from nonviral hepatitis or healthy subjects. C

SUBMITTER: Cobb DA 

PROVIDER: S-EPMC5739980 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature