Disrupted cortico-limbic connectivity during reward processing in remitted bipolar I disorder.

ABSTRACT:

Objectives

Bipolar disorder (BD) is associated with elevated reward sensitivity and persistent positive affect, yet the neural mechanisms underlying these patterns are not well understood. In the present study, we examined putative disruptions in communication within a well-known cortico-limbic reward circuit during reward processing as a potential contributing mechanism to these symptoms.

Methods

The present investigation employed a within- and between-subjects design utilizing a monetary and social incentive delay task among adults with bipolar disorder type I (BD; N = 24) and a healthy non-psychiatric control group (HC; N = 25) during functional magnetic resonance imaging (fMRI). Participants in the BD group were remitted at the time of testing.

Results

Functional

SUBMITTER: Dutra SJ 

PROVIDER: S-EPMC5739987 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature