RNA versatility, flexibility, and thermostability for practice in RNA nanotechnology and biomedical applications.

ABSTRACT: In recent years, RNA has attracted widespread attention as a unique biomaterial with distinct biophysical properties for designing sophisticated architectures in the nanometer scale. RNA is much more versatile in structure and function with higher thermodynamic stability compared to its nucleic acid counterpart DNA. Larger RNA molecules can be viewed as a modular structure built from a combination of many 'Lego' building blocks connected via different linker sequences. By exploiting the diversity of RNA motifs and flexibility of structure, varieties of RNA architectures can be fabricated with precise control of shape, size, and stoichiometry. Many structural motifs have been discovered and characterized over the years and the crystal structures of many of these motifs are available for nan

SUBMITTER: Haque F 

PROVIDER: S-EPMC5739991 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature