Genome-Wide Study of Subcutaneous and Visceral Adipose Tissue Reveals Novel Sex-Specific Adiposity Loci in Mexican Americans.

ABSTRACT:

Objective

This study aimed to explore the genetic mechanisms of regional fat deposition, which is a strong risk factor for metabolic diseases beyond total adiposity.

Methods

A genome-wide association study of 7,757,139 single-nucleotide polymorphisms (SNPs) in 983 Mexican Americans (n_male  = 403; n_female  = 580) from the Insulin Resistance Atherosclerosis Family Study was performed. Association analyses were performed with and without sex stratification for subcutaneous adipose tissue, visceral adipose tissue (VAT), and visceral-subcutaneous ratio (VSR) obtained from computed tomography.

Results

The strongest signal identified was SNP rs2185405 (minor allele frequencies [MAF] = 40%; P_VAT = 1.98 × 10^-8 ) with VAT. It is an i

SUBMITTER: Gao C 

PROVIDER: S-EPMC5740005 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature