Immunotoxicological impact and biodistribution assessment of bismuth selenide (Bi₂Se₃) nanoparticles following intratracheal instillation in mice.

ABSTRACT: Variously synthesized and fabricated Bi₂Se₃ nanoparticles (NPs) have recently been explored for their theranostic properties. Herein, we investigated the long term in-vivo biodistribution of Bi₂Se₃ NPs and systematically screened its immune-toxic potential over lungs and other secondary organs post intratracheal instillation. X-Ray CT scan and ICP MS results revealed significant particle localization and retention in lungs monitored for 1 h and 6 months time period respectively. Subsequent particle trafficking was observed in liver, the major reticuloendothelial organ followed by gradual but incomplete renal clearance. Pulmonary cytotoxicity was also found to be associated with persistent neutrophilic and ROS generation at all time points followi

SUBMITTER: Mishra V 

PROVIDER: S-EPMC5740059 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature