Cell Cycle Model System for Advancing Cancer Biomarker Research.

ABSTRACT: Progress in understanding the complexity of a devastating disease such as cancer has underscored the need for developing comprehensive panels of molecular markers for early disease detection and precision medicine applications. The present study was conducted to assess whether a cohesive biological context can be assigned to protein markers derived from public data mining, and whether mass spectrometry can be utilized to screen for the co-expression of functionally related biomarkers to be recommended for further exploration in clinical context. Cell cycle arrest/release experiments of MCF7/SKBR3 breast cancer and MCF10 non-tumorigenic cells were used as a surrogate to support the production of proteins relevant to aberrant cell proliferation. Information downloaded from the scientific pub

SUBMITTER: Lazar IM 

PROVIDER: S-EPMC5740075 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature