Potency of Meropenem-Vaborbactam in Lung Surfactant.

ABSTRACT: This study investigated whether pulmonary surfactant has an effect on the in vitro antibacterial activity of either meropenem alone or meropenem in combination with vaborbactam at a fixed concentration of 8 μg/ml against several Klebsiella pneumoniae carbapenemase (KPC)-producing strains of Gram-negative bacteria. Results showed that the potency of meropenem alone and that of meropenem-vaborbactam were not affected when tested with pulmonary surfactant.

SUBMITTER: Rubio-Aparicio D 

PROVIDER: S-EPMC5740353 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature