Antimicrobial Activities of Aztreonam-Avibactam and Comparator Agents against Contemporary (2016) Clinical Enterobacteriaceae Isolates.

ABSTRACT: A total of 10,451 contemporary (2016) Enterobacteriaceae isolates from 84 U.S. medical centers and 116 metallo-β-lactamase- and/or OXA-48-like-producing Enterobacteriaceae isolates from other countries were tested against aztreonam-avibactam and comparators. All U.S. isolates were inhibited at aztreonam-avibactam MICs of ≤8 μg/ml (MIC₅₀, ≤0.03 μg/ml; MIC₉₀, 0.12 μg/ml), including Klebsiella pneumoniae carbapenemase-producing isolates (n = 102; MIC₅₀, 0.25 μg/ml; MIC₉₀, 0.5 μg/ml), multidrug-resistant isolates (n = 876; MIC₅₀, 0.06 μg/ml; MIC₉₀, 0.25 μg/ml), and extensively drug-resistant isolates (n = 111; MIC₅₀, 0.12 μg/ml; MIC₉₀, 0.5 μg/ml). The highest aztreo

SUBMITTER: Sader HS 

PROVIDER: S-EPMC5740368 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature