Lung function discordance in monozygotic twins and associated differences in blood DNA methylation.

ABSTRACT:

Background

Lung function is an important predictor of morbidity and mortality, with accelerated lung function decline reported to have immense consequences for the world's healthcare systems. The lung function decline across individual's lifetime is a consequence of age-related changes in lung anatomical structure and combination of various environmental factors; however, the exact molecular mechanisms contributing to this decline are not fully understood. DNA methylation is an epigenetic modification that changes across individual's lifetime, as well as allows for interplay between environmental and genetic factors. DNA methylation plays a crucial role in regulation of gene expression, with increasing evidence linking aberrant DNA methylation levels with a number of common human d

SUBMITTER: Bolund ACS 

PROVIDER: S-EPMC5740718 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature