Association between genetic polymorphisms of the IL28B gene and leukomonocyte in Chinese hepatitis B virus-infected individuals.

ABSTRACT:

Background

Hepatitis B infection is one of the most severe hepatic diseases in China. Thus, understanding the genetic pathogenesis of hepatitis B virus (HBV)-infected individuals is important. Although no consistent result is obtained in different populations, HBV treatment effect is reportedly associated with the IL28B gene.

Methods

To investigate the role of the IL28B gene in HBV-infected individuals in Yunnan, China, we screened genotypes of three single nucleotide polymorphisms (SNPs, rs12979860, rs8099917, and rs12980275) in HBV-infected individuals and general controls by using SnapShot and sequencing.

Results

Results showed no significant difference was found in genotypes, alleles, and haplotypes frequency between the HBV-infected individuals and

SUBMITTER: Song Y 

PROVIDER: S-EPMC5740955 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature