Comment on "The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport".

ABSTRACT: O'Brien et al (Research Article, 24 February 2017, eaag1789) proposed a novel mechanism of primase function based on redox activity of the iron-sulfur cluster buried inside the C-terminal domain of the large primase subunit (p58C). Serious problems in the experimental design and data interpretation raise concerns about the validity of the conclusions.

SUBMITTER: Baranovskiy AG 

PROVIDER: S-EPMC5741086 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature