IL-2Rβ abundance differentially tunes IL-2 signaling dynamics in CD4⁺ and CD8⁺ T cells.

ABSTRACT: Interleukin-2 (IL-2) stimulates both activated CD4⁺ and CD8⁺ T cells to proliferate. IL-2 signals through an identical receptor complex and promotes the same dose-dependent phosphorylation of the canonical transcription factor STAT5 in both cell types. Despite this, CD8⁺ T cells enter the S phase earlier and proliferate to a greater extent than do CD4⁺ T cells in response to IL-2. We identified distinct IL-2 signaling dynamics in CD4⁺ and CD8⁺ T cells. In IL-2-stimulated CD8⁺ T cells, STAT5 phosphorylation increased rapidly and was sustained for 6 hours. In contrast, CD4⁺ T cells had a biphasic response, with maxima at 15 min and 2 to 4 hours after stimulation. Both cell types required vesicular traffic

SUBMITTER: Smith GA 

PROVIDER: S-EPMC5741096 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature