FGF23 Concentration and APOL1 Genotype Are Novel Predictors of Mortality in African Americans With Type 2 Diabetes.

ABSTRACT:

Objective

Cardiovascular and renal complications contribute to higher mortality in patients with diabetes. We assessed novel and conventional predictors of mortality in African American-Diabetes Heart Study (AA-DHS) participants.

Research design and methods

Associations between mortality and subclinical atherosclerosis, urine albumin-to-creatinine ratio (UACR), estimated glomerular filtration rate (eGFR), plasma fibroblast growth factor 23 (FGF23) concentration, African ancestry proportion, and apolipoprotein L1 genotypes (APOL1) were assessed in 513 African Americans with type 2 diabetes; analyses were performed using Cox proportional hazards models.

Results

At baseline, participants were 55.6% female with median (25th, 75th percentile) age 55 years (49.0, 62.

SUBMITTER: Chan GC 

PROVIDER: S-EPMC5741152 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature