Identify bilayer modules via pseudo-3D clustering: applications to miRNA-gene bilayer networks.

ABSTRACT: Module identification is a frequently used approach for mining local structures with more significance in global networks. Recently, a wide variety of bilayer networks are emerging to characterize the more complex biological processes. In the light of special topological properties of bilayer networks and the accompanying challenges, there is yet no effective method aiming at bilayer module identification to probe the modular organizations from the more inspiring bilayer networks. To this end, we proposed the pseudo-3D clustering algorithm, which starts from extracting initial non-hierarchically organized modules and then iteratively deciphers the hierarchical organization of modules according to a bottom-up strategy. Specifically, a modularity function for bilayer modules was proposed to

SUBMITTER: Xu Y 

PROVIDER: S-EPMC5741208 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature