A targeted approach to genome-wide studies reveals new genetic associations with central corneal thickness.

ABSTRACT:

Purpose

To evaluate the ability of a targeted genome-wide association study (GWAS) to identify genes associated with central corneal thickness (CCT).

Methods

A targeted GWAS was used to investigate whether ten candidate genes with known roles in corneal development were associated with CCT in two Singaporean populations. The single nucleotide polymorphisms (SNPs) within a 500 kb interval encompassing each candidate were analyzed, and in light of the resulting data, members of the Wnt pathway were subsequently screened using similar methodology.

Results

Variants within the 500 kb interval encompassing three candidate genes, DKK1 (rs1896368, p=1.32×10^-3), DKK2 (rs17510449, p=7.34×10^-4), and FOXO1 (rs7326616, p=1.56×10^-4

SUBMITTER: Benson MD 

PROVIDER: S-EPMC5741379 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature