Characterization of the Phospholipid Platelet-Activating Factor As a Mediator of Inflammation in Chickens.

ABSTRACT: Lipid mediators are known to play important roles in the onset and resolution phases of the inflammatory response in mammals. The phospholipid platelet-activating factor (PAF) is a pro-inflammatory lipid mediator which participates in vascular- and innate immunity-associated processes by increasing vascular permeability, by facilitating leukocyte adhesion to the endothelium, and by contributing to phagocyte activation. PAF exerts its function upon binding to its specific receptor, PAF receptor (PAFR), which is abundantly expressed in leukocytes and endothelial cells (ECs). In chickens, lipid mediators and their functions are still poorly characterized, and the role of PAF as an inflammatory mediator has not yet been investigated. In the present study we demonstrate that primary chicken mac

SUBMITTER: Garrido D 

PROVIDER: S-EPMC5741692 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature