Resequencing of the Leishmania infantum (strain JPCM5) genome and de novo assembly into 36 contigs.

ABSTRACT: Leishmania parasites are the causative of leishmaniasis, a group of potentially fatal human diseases. Control strategies for leishmaniasis can be enhanced by genome based investigations. The publication in 2005 of the Leishmania major genome sequence, and two years later the genomes for the species Leishmania braziliensis and Leishmania infantum were major milestones. Since then, the L. infantum genome, although highly fragmented and incomplete, has been used widely as the reference genome to address whole transcriptomics and proteomics studies. Here, we report the sequencing of the L. infantum genome by two NGS methodologies and, as a result, the complete genome assembly on 36 contigs (chromosomes). Regarding the present L. infantum genome-draft, 495 new genes have been annotated, a hundr

SUBMITTER: Gonzalez-de la Fuente S 

PROVIDER: S-EPMC5741766 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature