Palladium-Mediated Arylation of Lysine in Unprotected Peptides.

ABSTRACT: A mild method for the arylation of lysine in an unprotected peptide is presented. In the presence of a preformed biarylphosphine-supported palladium(II)-aryl complex and a weak base, lysine amino groups underwent C-N bond formation at room temperature. The process generally exhibited high selectivity for lysine over other amino acids containing nucleophilic side chains and was applicable to the conjugation of a variety of organic compounds, including complex drug molecules, with an array of peptides. Finally, this method was also successfully applied to the formation of cyclic peptides by macrocyclization.

SUBMITTER: Lee HG 

PROVIDER: S-EPMC5741856 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature