Adult human periodontal ligament-derived stem cells delay retinal degeneration and maintain retinal function in RCS rats.

ABSTRACT:

Background

Retinal degeneration (RD) is a leading cause of irreversible blindness, affecting millions of people worldwide. Stem cell transplantation has been considered a promising therapy for retinal degenerative diseases. This study aimed to investigate the therapeutic potential of human periodontal ligament-derived stem cells (hPDLSCs) for intervention in the progress of this degeneration in the Royal College Surgeons (RCS) rat.

Methods

hPDLSCs were injected into the subretinal space of 3-week-old RCS rats. Control animals received a phosphate-buffered saline injection or were untreated. Retinal function was assessed by electroretinography recording. Eyes were collected afterward for histology and molecular studies.

Results

Retinal function maintenance was observed

SUBMITTER: Huang L 

PROVIDER: S-EPMC5741902 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature